Ihomoni yesityalo i-abscisic acid (ABA) ngumlawuli obalulekileyo kwisityalo sokuziqhelanisa noxinzelelo lwe-abiotic.Ukulawulwa kweprotheyini ye-co-receptor PP2C efana ne-ABI1 yindawo ephakathi ye-ABA yokutshintshwa komqondiso.Ngaphantsi kweemeko eziqhelekileyo, i-ABI1 ibophelela kwiprotein kinase SnRK2s kwaye inqanda umsebenzi wayo.I-ABA ibophelelwe kwiprotheni ye-receptor ye-PYR1 / PYLs ikhuphisana ne-SnRK2s ekujoliseni i-ABI1, ngaloo ndlela ikhulula i-SnRK2 kwaye isebenze impendulo ye-ABA.
Iqela lophando elikhokelwa nguNjingalwazi u-Xie Qi ovela kwiZiko leGenetics kunye ne-Biology yoPhuhliso ye-Academy yaseShayina yeSayensi sele kudala ifunda indawo yonke, indlela yokuguqula emva koguqulelo olulawula ukubonakaliswa kwe-ABA.Umsebenzi wabo wangaphambili ubonise i-endocytosis ye-PYL4 edibeneyo yi-ubiquitination ye-protein ye-E2 efana ne-VPS23, kwaye i-ABA ikhuthaza i-XBAT35 ukuthotywa kwe-VPS23A, ngaloo ndlela ikhulula umphumo wokuthintela kwi-ABA receptor PYL4.Nangona kunjalo, ingaba ukubonakaliswa kwe-ABA kubandakanya iiprotheyini ezithile ze-E2 ezifunekayo kwi-ubiquitination, kunye nendlela umqondiso we-ABA olawula ngayo indawo yonke ayikaqondwa ngokupheleleyo.
Kutshanje, bachonge i-enzyme ethile ye-E2 UBC27, elawula ngokufanelekileyo ukunyamezela imbalela kunye nokuphendula kwe-ABA kwizityalo.Ngokusebenzisa uhlalutyo lwe-IP/MS, banqume ukuba i-ABA co-receptor ABI1 kunye ne-RING-type E3 ligase AIRP3 zisebenzisana neeprotheni ze-UBC27.
Bafumanise ukuba i-UBC27 isebenzisana ne-ABI1 kwaye ikhuthaze ukuthotywa kwayo, kwaye ivule umsebenzi we-E3 we-AIRP3.I-AIRP3 isebenza njenge-E3 ligase ye-ABI1.
Ukongeza, i-ABI1 isebenzisa i-epistasis ye-UBC27 kunye ne-AIRP3, ngelixa umsebenzi we-AIRP3 uxhomekeke ku-UBC27.Ukongeza, unyango lwe-ABA lubangela ukubonakaliswa kwe-UBC27, inqanda ukuthotywa kwe-UBC27, kwaye iphucula intsebenziswano phakathi kwe-UBC27 kunye ne-ABI1.
Ezi ziphumo zityhila i-E2-E3 entsha eyinkimbinkimbi ekuthotyweni kwe-ABI1 kunye nommiselo obalulekileyo kunye onzima wokubonakaliswa kwe-ABA yinkqubo ye-ubiquitination.
Isihloko sephepha sithi "UBC27-AIRP3 ubiquitination complex ilawula ukubonakaliswa kwe-ABA ngokukhuthaza ukuthotywa kwe-ABI1 e-Arabidopsis thaliana."Yapapashwa kwi-intanethi kwi-PNAS nge-19 ka-Okthobha, 2020.
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