Ubushakashatsi bwinshi bwakozwe mu myaka icumi ishize bwerekanye ko imiti yica udukoko ari yo nyirabayazana w’indwara ya Parkinson, ikaba ari indwara ya neurodegenerative yangiza imikorere ya moteri kandi ikababaza miliyoni y'Abanyamerika.Nyamara, abahanga ntibarasobanukirwa neza nuburyo iyi miti yangiza ubwonko.Ubushakashatsi buherutse gukorwa bwerekana igisubizo gishoboka: imiti yica udukoko irashobora kubuza inzira ya biohimiki isanzwe irinda neuron ya dopaminergique, ari selile yubwonko yibasirwa nindwara.Ubushakashatsi bwibanze bwerekanye kandi ko ubu buryo bushobora kugira uruhare mu ndwara ya Parkinson kabone niyo hataba hakoreshejwe imiti yica udukoko, bitanga intego nshya zishimishije zo guteza imbere ibiyobyabwenge.
Ubushakashatsi bwashize bwerekanye ko umuti wica udukoko witwa benomyl, nubwo wabujijwe muri Amerika kubera impungenge z’ubuzima mu 2001, uracyari mu bidukikije.Irabuza aldehyde dehydrogenase mu mwijima (ALDH) ibikorwa bya shimi.Abashakashatsi bo muri kaminuza ya Californiya, Los Angeles, kaminuza ya Californiya, Berkeley, Ikigo cy’ikoranabuhanga cya Kaliforuniya, n’ikigo cy’ubuvuzi cya Veterans Affairs Centre ya Greater Los Angeles bifuzaga kumenya niba iyi miti yica udukoko nayo izagira ingaruka ku rwego rwa ALDH mu bwonko.Akazi ka ALDH nugusenyera imiti isanzwe yuburozi DOPAL kugirango itagira ingaruka.
Kugirango babimenye, abashakashatsi berekanye ubwoko butandukanye bwingirabuzimafatizo zubwonko bwabantu hanyuma zebrafish yose kuri benomyl.Umwanditsi wabo mukuru akaba na kaminuza ya Californiya, Los Angeles (UCLA) umuhanga mu by'imitsi witwa Jeff Bronstein (Jeff Bronstein) yavuze ko basanze “byishe hafi kimwe cya kabiri cya neurone ya dopamine, mu gihe izindi neurone zose zitigeze zipimwa.”Ati: "Iyo zeru kuri selile zanduye, bemeje ko benomyl yabujije rwose ibikorwa bya ALDH, bityo bigatuma uburozi bwa DOPAL bwiyongera.Igishimishije, mugihe abahanga bakoresheje ubundi buhanga kugirango bagabanye urugero rwa DOPAL, benomyl ntabwo yangije neuron ya dopamine.Ubu bushakashatsi bwerekana ko umuti wica udukoko wica iyi neuron kuko ituma DOPAL yegeranya.
Kubera ko indi miti yica udukoko nayo ibuza ibikorwa bya ALDH, Bronstein avuga ko ubu buryo bushobora gufasha gusobanura isano iri hagati y’indwara ya Parkinson n’imiti yica udukoko muri rusange.Icy'ingenzi cyane, ubushakashatsi bwerekanye ko ibikorwa bya DOPAL ari byinshi cyane mu bwonko bw’abarwayi ba Parkinson.Aba barwayi ntibagaragaye cyane imiti yica udukoko.Kubwibyo, tutitaye kubitera, iyi nzira ya biohimiki cascade irashobora kugira uruhare mubikorwa byindwara.Niba ibi ari ukuri, noneho imiti ihagarika cyangwa ikuraho DOPAL mu bwonko irashobora kwerekana ko ari uburyo bwiza bwo kuvura indwara ya Parkinson.