Asayansi akuwulula njira yatsopano yoyendetsera E2-E3 yovuta UBC27-AIRP3 pa abscisic acid co-receptor ABI1.

Hormone ya zomera abscisic acid (ABA) ndiyomwe imathandizira kusintha kwazovuta za zomera.Kuwongolera kwa mapuloteni a co-receptor PP2C ngati ABI1 ndiye chigawo chapakati cha ABA chosinthira chizindikiro.Pansi pamikhalidwe yokhazikika, ABI1 imamanga ku protein kinase SnRK2s ndikulepheretsa ntchito yake.ABA yomangidwa ndi mapuloteni olandirira PYR1/PYLs amapikisana ndi SnRK2s polunjika ABI1, potero amamasula SnRK2s ndikuyambitsa kuyankha kwa ABA.
Gulu lofufuza motsogozedwa ndi Pulofesa Xie Qi wochokera ku Institute of Genetics and Developmental Biology ya Chinese Academy of Sciences akhala akuphunzira kwa nthawi yayitali, njira yosinthira pambuyo pomasulira yomwe imayang'anira kusaina kwa ABA.Ntchito yawo yapitayi idavumbulutsa endocytosis ya PYL4 yomwe imayanjanitsidwa ndi kupezeka kwa mapuloteni a E2-ngati VPS23, ndipo ABA imalimbikitsa XBAT35 kuti iwononge VPS23A, potero imatulutsa zotsatira zoletsa pa ABA receptor PYL4.Komabe, ngati chizindikiro cha ABA chimaphatikizapo mapuloteni enieni a E2 omwe amafunikira kuti apezeke ponseponse, komanso momwe chizindikiro cha ABA chimayendetsera kufalikira sikunamveke bwino.
Posachedwapa, adazindikira enzyme ya E2 UBC27, yomwe imayendetsa bwino kulekerera chilala ndi kuyankha kwa ABA muzomera.Kupyolera mu kusanthula kwa IP/MS, adatsimikiza kuti ABA co-receptor ABI1 ndi RING-type E3 ligase AIRP3 akulumikizana mapuloteni a UBC27.
Adapeza kuti UBC27 imalumikizana ndi ABI1 ndikulimbikitsa kuwonongeka kwake, ndikuyambitsa ntchito ya E3 ya AIRP3.AIRP3 imagwira ntchito ngati E3 ligase ya ABI1.
Kuphatikiza apo, ABI1 imakhala ndi epistasis ya UBC27 ndi AIRP3, pomwe ntchito ya AIRP3 imadalira UBC27.Kuphatikiza apo, chithandizo cha ABA chimapangitsa kufotokoza kwa UBC27, kumalepheretsa kuwonongeka kwa UBC27, ndikuwonjezera kuyanjana pakati pa UBC27 ndi ABI1.
Zotsatirazi zikuwonetsa zovuta zatsopano za E2-E3 pakuwonongeka kwa ABI1 komanso kuwongolera kofunikira komanso kovuta kwa ABA kusaina ndi dongosolo la ubiquitination.
Mutu wa pepala ndi "UBC27-AIRP3 ubiquitination complex imayang'anira kusaina kwa ABA polimbikitsa kuwonongeka kwa ABI1 ku Arabidopsis thaliana."Idasindikizidwa pa intaneti pa PNAS pa Okutobala 19, 2020.
Mungakhale otsimikiza kuti ogwira ntchito mkonzi adzayang'anitsitsa ndemanga zonse zomwe zatumizidwa ndipo adzachitapo kanthu.Malingaliro anu ndi ofunika kwambiri kwa ife.
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Tumizani zosintha za sabata ndi/kapena zatsiku ndi tsiku kubokosi lanu.Mutha kusiya kulembetsa nthawi iliyonse, ndipo sitidzagawana zambiri ndi anthu ena.
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Nthawi yotumiza: Dec-07-2020