Kafukufuku wambiri m'zaka khumi zapitazi wasonyeza kuti mankhwala ophera tizilombo ndi omwe amayambitsa matenda a Parkinson, omwe ndi matenda a neurodegenerative omwe amalepheretsa kugwira ntchito kwa magalimoto ndipo amavutitsa anthu miliyoni a ku America.Komabe, asayansi sakumvetsabe mmene mankhwalawo amawonongera ubongo.Kafukufuku waposachedwa akuwonetsa yankho lotheka: mankhwala ophera tizilombo amatha kulepheretsa njira zama biochemical zomwe nthawi zambiri zimateteza ma dopaminergic neurons, omwe ndi maselo aubongo omwe amawukiridwa ndi matenda.Kafukufuku woyambirira wasonyezanso kuti njira imeneyi ingathandize ku matenda a Parkinson ngakhale popanda kugwiritsa ntchito mankhwala ophera tizilombo, kupereka zolinga zatsopano zosangalatsa za chitukuko cha mankhwala.
Kafukufuku wam'mbuyo wasonyeza kuti mankhwala ophera tizilombo otchedwa benomyl, ngakhale kuti analetsedwa ku United States chifukwa cha thanzi mu 2001, adakalipobe m'chilengedwe.Imalepheretsa aldehyde dehydrogenase m'chiwindi (ALDH) ntchito yamankhwala.Ofufuza ku yunivesite ya California, Los Angeles, University of California, Berkeley, California Institute of Technology, ndi Veterans Affairs Medical Center ya Greater Los Angeles ankafuna kudziwa ngati mankhwala ophera tizilombo angakhudzenso mlingo wa ALDH mu ubongo.Ntchito ya ALDH ndikuwola mankhwala oopsa omwe amapezeka mwachilengedwe a DOPAL kuti akhale opanda vuto.
Kuti adziwe, ofufuzawo adawulula mitundu yosiyanasiyana ya ma cell aubongo wamunthu ndipo kenako zebrafish yonse kukhala benomyl.Wolemba wawo wamkulu komanso katswiri wa zaubongo ku University of California, Los Angeles (UCLA) Jeff Bronstein (Jeff Bronstein) ananena kuti anapeza kuti “zinapha pafupifupi theka la ma dopamine neurons, pamene ma neuron ena onse sanayesedwe.”"Atayang'ana ma cell omwe adakhudzidwa, adatsimikizira kuti benomyl imalepheretsadi ntchito ya ALDH, zomwe zimachititsa kuti DOPAL adziunjike.Chosangalatsa ndichakuti, pamene asayansi adagwiritsa ntchito njira ina yochepetsera milingo ya DOPAL, benomyl sinawononge ma dopamine neurons.Zomwe anapezazi zikusonyeza kuti mankhwala ophera tizilombo amapha ma neuronwa chifukwa amalola kuti DOPAL iwunjikane.
Popeza mankhwala ena ophera tizilombo amalepheretsanso ntchito ya ALDH, Bronstein akuganiza kuti njirayi ingathandize kufotokoza kugwirizana pakati pa matenda a Parkinson ndi mankhwala ophera tizilombo.Chofunika kwambiri, kafukufuku wapeza kuti zochita za DOPAL ndizokwera kwambiri muubongo wa odwala matenda a Parkinson.Odwalawa sanavutike kwambiri ndi mankhwala ophera tizilombo.Chifukwa chake, mosasamala kanthu zomwe zimayambitsa, izi zam'magazi zam'magazi zimatha kutenga nawo gawo munjira ya matendawa.Ngati izi ndi zoona, ndiye kuti mankhwala omwe amaletsa kapena kuchotsa DOPAL mu ubongo akhoza kukhala chithandizo chodalirika cha matenda a Parkinson.