Yes, there are several alternatives to Metalaxyl fungicide, especially when targeting oomycete pathogens like Phytophthora, Pythium, and downy mildew. These alternatives vary in mode of action, systemic properties, and efficacy against different diseases, making them useful for fungicide rotation to manage resistance. Here are some key alternatives:

1. Metalaxyl-M (Mefenoxam)

• Mode of Action: Similar to Metalaxyl, as it is an isomer, but generally considered more effective at lower doses.
• Target Diseases: Broad control over oomycete pathogens like Phytophthora, Pythium, and downy mildew.
• Applications: Used in many of the same crops as Metalaxyl, including potatoes, tomatoes, grapes, and vegetables. Ideal for managing resistance in rotation with Metalaxyl.

2. Phosphonates (Phosphorous Acid Compounds)

• Mode of Action: Induce systemic resistance in plants and inhibit growth of oomycetes.
• Target Diseases: Effective against Phytophthora, downy mildew, and other oomycete pathogens.
• Applications: Applied as foliar sprays, drenches, or trunk injections in crops like citrus, avocados, grapes, and ornamentals. Can be used preventively and has minimal resistance issues.

3. Dimethomorph

• Mode of Action: Inhibits cell wall synthesis in oomycete pathogens.
• Target Diseases: Effective against downy mildew, Phytophthora root rot, and late blight.
• Applications: Often mixed with other fungicides like Mancozeb or Metalaxyl for added efficacy. Used on crops like grapes, potatoes, tomatoes, and cucurbits.

4. Cymoxanil

• Mode of Action: A locally systemic fungicide that disrupts pathogen growth in the early stages.
• Target Diseases: Primarily effective against downy mildew and late blight.
• Applications: Often used in tank mixes with other fungicides, like Mancozeb or chlorothalonil, for broad-spectrum protection in crops like potatoes, grapes, and tomatoes.

5. Fluopicolide

• Mode of Action: Disrupts pathogen cellular structure by targeting lipid biosynthesis.
• Target Diseases: Downy mildew, late blight, and other oomycete diseases.
• Applications: Commonly used in combination with other fungicides, such as propamocarb, in crops like cucurbits, leafy greens, and grapes.

6. Propamocarb

• Mode of Action: Inhibits cell membrane formation in oomycetes.
• Target Diseases: Highly effective against Pythium and Phytophthora species, as well as damping-off in vegetables.
• Applications: Primarily used as a soil drench or seed treatment in crops like tomatoes, cucurbits, and leafy vegetables.

7. Mancozeb (Non-Systemic Contact Fungicide)

• Mode of Action: Multi-site action against cell components of fungi, making it less prone to resistance.
• Target Diseases: Broad-spectrum, including downy mildew and leaf spots.
• Applications: Often tank-mixed with systemic fungicides like Metalaxyl or cymoxanil to enhance efficacy. Used on various fruits, vegetables, and ornamental plants.

Summary Table of Metalaxyl Alternatives

Best Practice: Resistance Management

Since oomycete pathogens can develop resistance, rotating these fungicides or using them in combination can improve effectiveness and delay resistance development. For instance:

• Rotate Metalaxyl with non-systemic options like Mancozeb or copper-based fungicides.
• Tank-mix Metalaxyl with Cymoxanil or Dimethomorph for dual action on oomycetes.

These alternatives provide flexible, effective options to protect a wide range of crops while managing resistance risk in integrated pest management (IPM) programs.